INACTIVATED VIRAL VACCINES

A second approach has been to inactivated the domains of two nucleocapsid protein zinc fingers. This has been achieved by treating these complexes with mild oxidation or alkylation procedures, which completely inactivates both HIV-1 and SIV but keeps the envelope glycoprotein spikes intact and functional. Studies in the SIV macaque model revealed that monkeys vaccinated with the inactivated virus were not protected against infection with the wild-type virus, but the level of SIV viremia were low and there was  no depletion of CD4 T cells.