A second animal model of HIV vaccine research is based on the use of SIV/HIV hybrid viruses that were enginered to carry the env gene from HIV into the content of the SIV genome. These viruses do replicate in rhesus macaques and after serial macaque passages do lead to the emergence of highly pathogenic SHIV variants that can wipe out circulating CD4 T cells within a few weeks and lead to a lethal immunodeficiency syndrome within a year of infection.

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