IMMUNOLOGY OF HIV INFECTIONS part 6

HIV AIDS 1

 

In summary, the selective effects of the NEF protein may markedly  enhance viral pathogenesis and progression to disease. It does this by hijacking DC functional activity and favoring HIV replication via bystander activation  of CD4 cells and the escape of HIV-1 from immune surveillance by blocking NEF influence in viral replication may have long-term beneficial effects on therapeutic management of the disease.

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