A hypothesis such as this implies that it might be possible to detect clonal expansions in healthy subjects. In fact, small numbers of apparently clonal B cells with B-CLL cell characteristics do exist in the blood of about 3.5% of disease-free individuals. An even higher proportion of such clones have been found in the blood of first-degree relatives of patients with B-CLL (as often as 12%). Although such studies of the BCRs of B lymphocyte expansions in normal disease-free individuals are limited, they further support this hypothesis in that these expansions are not only monoclonal but also use some of the same genes commonly encoding the BCRs of B-CLL clones.
Been diagnosed. My WBC has been 15,000 to 18,000 for thirty five years. No treatment, no recognizable side effects.
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Acute Biphenotypic Leukemia is a rare and heterogeneous type of blood cancer, which is alternatively called mixed phenotype acute leukemia (MPAL) or hybrid leukemia.The Hematopoietic or blood developing stem cell therapy offers the best treatment options for Biphenotypic Acute Leukemia: https://bit.ly/2H8o6Wh
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