CHRONIC LYMPHOCYTIC LEUKEMIA part 16

Leukemia 2

 

With continued expansion leading (or not) to accumulation of IgVH gene mutations as explained by the T-cell-dependent versus T-cell-independent models mentioned earlier, it becomes increasingly likely that a cell develops a genetic abnormality as in an initial inducing lesion that would lead to relatively unrestrained expansion. Such a cell is primed for leukemic transformations.

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