DEVELOPMENT OF B-CELL FROM NORMAL B LYMPHOCYTES:
SIGNALS AND MECHANISMS INITIATING THE GROWTH AND ACCUMULATION OF LEUKEMIC LYMPHOCYTES
The major events in tumorigenesis have traditionally been grouped into inducing and promoting factors. Inducing factors cause transforming mutations, whereas promoting factors sustain the proliferation and survival of cells undergoing or having undergone transforming mutations. It is useful to apply such principles to B-CLL.