AUTOIMMUNITY part 70

Immune 4

 

Unlike cyclophosphamide and azathioprine, cyslosporin and tacrolimus (FK506) have immunosuppressive properties that are highly selective for T cells. Both agents interfere with the phosphatase calcineurin, ultimately leading to an inhibition of the activation of the transcription factor NFAT (nuclear factor of activated T cells). Cyclosporine binds to the intracellular protein cyclophilin and tacrolimus-FK binding protein complexes bind to calcineurin, preventing its activation by intracellular calcium, and the activation of NFAT. Although used most frequently to prevent transplant rejection, these agents have been shown to have activity in the treatment of RA, SLE, and certain forms of vasculities.

Advertisements

About azaleaazelia

A nice person... :)
This entry was posted in Tak Berkategori. Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s