AUTOIMMUNITY part 61

Immune 4

 

Finally, antigen presenting cells play an important role in the induction of tolerance. Dendritic cells can either initiate T-cell activation and proliferation or promote peripheral  tolerance through the deletion of autoreactive T cells, depending on their maturation state. Tolerance is induced when antigens are presented by immature dendritic cells and these cells also play a role in the generation and maintenance of Treg.

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