AUTOIMMUNITY part 59

Immune 4

 

Many self-antigens are expressed at  a  very low level that is insufficient to induce T-cell activation. In the case of T cells, which recognize short peptides associated with MHC molecules, the induction of self-tolerance requires the generation of a sufficient amount of self peptide in antigen-presenting cells to stimulate T-cell deletion or anergy. Self-peptides that are generated inefficiently by the antigen-presenting cells can neither stimulate immunity nor induce tolerance; that is, the immune system remains “ignorant” of them.  If these minor self-peptides are produced in larger amounts and exposed to the immune system in the presence  of an inducer of co-stimulatory molecules (eg adjuvants), they have the capacity to stimulate an immune response.  This has been shown experimentally with peptides generated in vitro using proteolytic enzymes or using synthetic self peptides.

Advertisements

About azaleaazelia

A nice person... :)
This entry was posted in Tak Berkategori. Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s