AUTOIMMUNITY part 56

Immune 4

 

Infection also are implicated in the pathogenesis of autoimmune disease. The classic example is rheumatic fever, which is thought to be a consequence of cross-reactivity or “molecular mimicry” between antigens carried by certain strains of streptococci and self-antigens of the heart.Mycoplasma pneumonia can induce the production of cold agglutinins, polyclonal cold-reactive IgM autoantibodies  against the erythrocyte I, or i antigens that can cause complement-mediated AIHA. A variety of other parasitic (eg, schistosomiasis, Chagas’ disease), bacterial (eg, Helicobacter pylori, staphylococci, salmonella, Lyme borreliosis), mycobacterial (eg, tuberculosis, leprosy), and viral (eg, cytomegalovirus, Epstein-Barr virus, hepatitis C, Coxsackie virus, parvovirus B19) infection can be complicated by autoimmunity. Proposed mechanisms include molecular mimicry and the chronic overproduction of cytokines, such as IFN-α. Indeed, therapy with IFN-α can lead to the development of autoimmune diseases such as autoimmune thyroiditis and SLE

Advertisements

About azaleaazelia

A nice person... :)
This entry was posted in Tak Berkategori. Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s