AUTOIMMUNITY part 41

Immune 4

 

COLLAGEN INDUCED ARTHRITIS (CIA)

Immunization of susceptible rodent strains with type II collagen (CII) leads to the development of a severe polyarticular arthritis resembling human RA. Although induced by heterologous CII, immunization leads to a response against autologous CII. CIA can be induced in susceptible strains of mice, rats and primates. Histologucally, both RA and CIA are characterized  by an intense synovitis accompanied by erosion of cartilage and subchondral bone by a pannuslike tissue. Unlike human RA, CIA is monophasic. In addition, there are important serological differences. In general, rheumathoid factor is not produced in CIA and antibodies against CCP are absent.

Advertisements

About azaleaazelia

A nice person... :)
This entry was posted in Tak Berkategori. Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s