COLLAGEN INDUCED ARTHRITIS (CIA)
Immunization of susceptible rodent strains with type II collagen (CII) leads to the development of a severe polyarticular arthritis resembling human RA. Although induced by heterologous CII, immunization leads to a response against autologous CII. CIA can be induced in susceptible strains of mice, rats and primates. Histologucally, both RA and CIA are characterized by an intense synovitis accompanied by erosion of cartilage and subchondral bone by a pannuslike tissue. Unlike human RA, CIA is monophasic. In addition, there are important serological differences. In general, rheumathoid factor is not produced in CIA and antibodies against CCP are absent.