AUTOIMMUNITY part 40

Immune 4

 

Rheumatoid arthritis (collagen-induced arthritis, TTP deficiency, K/BxN model)

Rheumathoid arthritis (RA) is a systemic autoimmune disease characterized by prominent joint involvement. Arthritis is typically associated with erosion of cartilage and subchondral bone, formation of an inflammatory tissue, consisting of activated macrophages, T cells, fibroblast, and other immune cells (pannus). This can ultimately result in joint destruction and significant joint deformities. In addition to the joints, RA can cause vasculitis, splenomegaly and leukopenia (Felty’s syndrome), interstitial lung disease, and other abnormalities. Rheumatoid factor (an autoantibody against the Fc portion of immunoglobulin) and antibodies against citrulline-modified proteins or peptides 9usually detected as antibodies against an artificially produced cyclic citrullinated peptide, or CCP) are typical serological finding in RA, although not all patients exhibits these abnormalities. Several animal models of RA exist, but they do not precisely reproduce the clinicel and laboratory abnormalities.

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