AUTOIMMUNITY part 39

Immune 4

 

TMPD-INDUCED LUPUS

Intraperitoneal injection of pristane (2,6,10,14 tetramethylpentadecane, TMPD)  can induce a lupus-like syndrome in non-autoimmune-prone mice characterized by proliferative glomerulonephritis, erosive arthritis, pulmonary vasculitis, and a variety of lupus autoantibodies, including anti ds-DNA and anti-Sm. All of nearly all immunocompetent mouse strains are susceptible to lupus induced by this hydrocarbon oil. This inducible model of lupus is,  at least so far, unique in reproducing  the increased levels of IFN-α and IFN-β seen in the majority of lupus patients. The disease is largely abrogated in type I interferon receptor deficient mice.

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