Immune 4



This strain was created by crossing male SB/Le and female C57BL/6J mice. Male, but not female, BXSB mice develop severe glomerulonephritis, lymphadenopathy, splenomegaly, AIHA, and anti-dsDNA autoantibodies. Thus, the sex predilection is an important difference from human lupus and most other murine lupus models. A mutant gene located on the Y chromosome, designated Yaa (Y chromosome-linked autoimmune acceleration), causes accelerated lupus-like disease in male BXSB mice. A recent study showed that the Yaa mutation results from translocation of a 4-megabase portion of the X chromosome to the Y chromosome, leading to increased expression of several genes that are normally X linked, including TLR7

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