AUTOIMMUNITY part 35

Immune 4

 

SLE (NZB X NZW F1, MRL, BXSB, TMPD)

Numerous mouse strains have been studied over the years as animal models of SLE. Some strains develop lupus spontaneously, such as NZB X NZW (F1) (NZB/W) hybrid mice, MRL mice, and BXSB male mice. Other models, such as tetramethyl-pentadecane (TMPD, pristane) induced lupus, are inducible with chemicals. The spontaneous models afford hope that if the genetic defect(s) responsible for lupus like disease in these mice can be identified, similar defects will be found in human lupus. However, the inducible TMPD model more closely mimics the abnormalities in interferon (IFN) α and β production seen in most lupus patients.

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