ANIMAL MODELS OF AUTOIMMUNE DISEASE
The difficulty in carrying out randomized, well controlled research in patients complicates studies of the pathogenesis and treatment of human autoimmune disease. Often the simplest course is to first study the disease in an appropriate animal model. However, because animal models of disease rarely are identical to the human disorder, the suitability of a particular model in any given situation must be considered carefully before undertaking animal studies. The list of animal models of autoimmune disease is extensive, and only some of the more commonly studied models can be reviewed.