Immunological aspects of immunodeficiency diseases part 110

Immune 3


Defective NFκB activation caused by X-linked hypomorphic mutations of the essential modulator gene (NEMO) compromises signaling mechanisms downstream of Toll, IL-1, and TNF-α receptors. These patients are susceptible to infections caused by a range of microorganisms, including mycobacteria, Gram-positive and Gram negative bacteria, fungi and viruses.

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