Immunological aspects of immunodeficiency diseases part 103

Immune 3

 

COMPLEMENT DEFICIENCY AND AUTOIMMUNITY

Under physiological conditions, activation of the classical complement pathway helps in the clearance of the circulating immune complexes by the resident macrophages of the reticuloendothelial system. The surface of apoptotic cells activates the classical complement pathway, leading to their efficient clearance by phagocytic cells expressing complement receptors, preventing the generation of autoimmune responses to cellular components.

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