Immunological aspects of immunodeficiency diseases part 90

Immune 3


The pathological manifestations of the XLP cannot be  completely attributed to the reduced NK- and T-cell function seen in this condition. The SAP, which acts as a signaling adaptor molecule within lymphoid cells, and XIAP, which regulates apoptosis, help in the homeostasis of immune responses in complex ways. Therefore, mechanisms underlying the pathogenesis of XLP are likely to be complicated.

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