Immunological aspects of immunodeficiency diseases part 86

Immune 3

 

Mutation of the perforin  (PRF1) gene, which encodes for perforin, is one of the genetic  defects that predisposes to familial HLH. Perforin-supported cytolysis (by CD-8 cells and NK cells) may damp down immune responses triggered by viral infections by aiding the elimination of antigen-presenting cells or by promoting activation-induced death of  T-cells.

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