Immunological aspects of immunodeficiency diseases part 81

Immune 3

 

DNA REPAIR DEFECTS ASSOCIATED WITH IMMUNODEFICIENCY

ATAXIA TELANGIECTASIA

Ataxia telangiectasia (AT) is a condition characterized by cerebellar ataxia, oculocutaneous telangiectasia, growth retardation and a variable immunodeficiency. AT patients show increased sensitivity to ionized radiation and radiomimetic drugs. Increased susceptibilityto leukemias and lymphomas is also a feature of this syndrome, Patients often fail to produce antibodies to bacterial capsular polisaccharides and therefore develop sinopulmonary infections. Chromosomal translocations, involving immunoglobulin heavy chain and TCR loci, are often detected in the T cells of AT patients.

About azaleaazelia

A nice person... :)
This entry was posted in Tak Berkategori. Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s