Immunological aspects of immunodeficiency diseases part 72

Immune 3

 

The cytosolic GTPase Rac2 is required for the normal actin polymerization and optimal function of the phagocyte oxidase system. Rac2 deficiency results in impaired neutrophil mobility and poor superoxide responses to some stimuli. A single affected patient identified to date had a clinical presentation similar to that seen in LAD.

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