Immunological aspects of immunodeficiency diseases part 69

Immune 3


In CGD, the bacterial killing mechanisms that depend on the phagocyte oxidase system are inoperative, but the nonoxidative killing mechanisms are still intact. Therefore, patients with CGD are not troubled by the broad range of microbes that a neutropenic patient would be susceptible to. Instead, CGD patients get infections a restricted range of microorganisms, which are only susceptible to the bactericidal mechanisms initiated by NADPH oxidase activation. The spectrum of organisms that causes infections in CGD  include S. aureus, Gram-negative bacteria (Burkholderia cepacea, Salmonella, Serratia), and fungi (Aspergillus spp). Characteristic sites of infection  include subcutaneous tissue,  lymph nodes, lungs, and liver. Oral and perioral ulceration are common.


About azaleaazelia

A nice person... :)
This entry was posted in Tak Berkategori. Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s