Immunological aspects of immunodeficiency diseases part 55

 

 

Immune 3

 

Mutations in proteins required for normal functioning and signal transduction through the T-cell receptor (TCR) cause rare forms of SCID. Mutations of the tyrosine phosphatase, CD45, which helps to initiate signaling by the TCR, results in T-B+SCID in humans. Mutations of components of CD3-complex (CD3 γ, ε, δ) result in a SCID phenotype. During signal transduction via TCRs, the protein tyrosine kinases lck and ZAP70 are required for phosphorilation of ITAMs on the intracytoplasmic segment of the TCR. Deficiency of either of these kinases results in rare forms of SCID

Advertisements

About azaleaazelia

A nice person... :)
This entry was posted in Tak Berkategori. Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s