Immunological aspects of immunodeficiency diseases part 53

Immune 3

 

T- and B-cell antigen receptors are assembled from the recombinations of variable region V(D)J and constant region genes. A protein called ARTEMIS is required for DNA repair, including the repair of DNA breaks generated during V(D)J recombinations. Mutation of the gene encoding ARTEMIS results in a rare form of T-B-SCID. These patients also exhibit increased sensitivity to ionizing radiation.

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