Immunological aspects of immunodeficiency diseases part 51

Immune 3


In humans, T-B-SCID is most common (50% of total) caused by mutations of the recombinase-activating genes, RAG1 or RAG2. RAG1 and RAG2 are enzymes responsible for introducing double stranded DNA breaks, which initiate V(D)J gene rearrangements required for generating T- and B-cell receptors for antigen. Without normal RAG1 and RAG2 function, T- and B-cell development is arrested early in ontogeny, producing T-B-SCID.

About azaleaazelia

A nice person... :)
This entry was posted in Tak Berkategori. Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s