Immunological aspects of immunodeficiency diseases part 44

Immune 3

 

MANIFESTATIONS OF T-CELL DEFICIENCY

KEY CONCEPTS

Patients with impaired T-cell function may develop the following:

Malignancies: T-cell-deficient individuals are prone to develop a range of malignancies where viral infection act as co-factor (eg Epstein-Barr virus induced  non-Hodgkin’s lymphma, Kaposi’s sarcoma where herpes virus 8 is a co-factor). There is also an increase  in cutaneous malignancies occuring in an individual exposed to significant amounts of ultraviolet light (basal-cell carcinoma and squamous carcinoma)

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