Immunological aspects of immunodeficiency diseases part 40

 

 

Immune 3

 

MANIFESTATIONS OF T-CELL DEFICIENCY

KEY CONCEPTS

Patients with impaired T-cell function may develop the following:

Fungal infections: T-cell-deficient patients are typically susceptible to fungal infections.

  • Pneumocystis giroveci causes interstitial pneumonia, which is pathognomonic for T-cell-deficiency
  • Mucocutaneous infection with Candida
  • Systemic infections with filamentous fungi (eg Aspergillus fumigatus)
  • Meningitis or systemic infection caused by Cryptococcus neoformans
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