Immunological aspects of immunodeficiency diseases part 35

Immune 3

 

Some individuals with IgG subclass deficiencies are asymptomatic. Others with IgG subclass deficiencies are prone to recurrent sinopulmonary infections. Such infection-prone patients exhibit reduced antibody responses to bacterial capsular polysaccharides. Defective anti-polysaccharide antibody responses are most often seen in individuals with IgG2 subclass deficiency with or without concomittant IgA deficiency. The molecular mechanisms underlying igG subclass deficiencies are unknown.

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