Immunological aspects of immunodeficiency diseases part 27

Immune 3

 

ICOS (inducible-co-stimulating receptor) is a co stimulatory T-cell molecule that induces cytokines required for supporting class-switch recombination, Ig production and terminal B-cell differentiation. ICOS -/- and ICOS ligand -/- mice exhibit defective germinal center formation and antibody production. Mutations in the ICOS gene account for about 1 percent of CVID patients.

Advertisements

About azaleaazelia

A nice person... :)
This entry was posted in Tak Berkategori. Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s