Immunological aspects of immunodeficiency diseases part 24

Immune 3

 

The immunological phenotype of CVID is heterogenous  with documented defects in B-cell survival, generation of B memory cells, and in vitro B- and T-cell activation. About 10 percent of cases of CVID are familial, with a predominance of autosomal dominant or autosomal recessive inheritance. CVID or selective IgA deficiency  can affect different members of gene defects have been identified in CVID patients, accounting for about 10-15 percent of the total patient pool.

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