Immunological aspects of immunodeficiency diseases part 15

Immune 3

 

MAJOR CATEGORIES OF ANTIBODY DEFICIENCY

ANTIBODY DEFICIENCY ASSOCIATED WITH ABSENT B CELLS

B-cell maturation  beyond the pre-B-cell stage found in bone marrow, requires signals received through the pre-B-cell receptor complex. The pre-B-cell receptor is composed of the μ chains, surrogate light chains (heterodimers of λ constant region with V pre-β), and the signal-transducing components Igα and Igβ. The activities of the protein BTK (Bruton’s tyrosine kinase) and BLNK (B-cell linker protein) are also essential for the transduction  of signals received via the B-cell (and pre-B-cell) receptors. Therefore, it is not surprising that mutations in each of these elements causes early-onset antibody deficiency associated with lack of circulating B cells.

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1 Response to Immunological aspects of immunodeficiency diseases part 15

  1. Hafizh says:

    thank you for yaur information

    Like

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