Immunological aspects of immunodeficiency diseases part 3

Immune 3


From clinical perspective, immunodeficiencies can be classified into eight categories. Each category has a characteristic pattern of clinical presentation, which will elaborated later.

Operational classification of immunodeficiency states;

  • Immunodeficiency due to defective anatomical or  physiological barriers to infection
  • Deficiency of opsonins (antibody deficiency and complement deficiency)
  • T-cell deficiency
  • Combined T- and B-cell deficiency
  • Phagocyte deficiency
  • Defects in macrophage activation
  • Defects in immunoregulation
  • Defects in homeostasis of inflammation

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