Immunological aspects of infections part 51

Immune System

 

Interestingly, there have been several mutations in the host that help provide resistance to malarial infection. Most striking has been the appearance of the heterozygous sickle cell trait (Hbas), which confers a survival advantage in endemic disease. Second, the absence of the red cell Duffy antigen (receptor for plasmodium vivax) is quite protective. Finally, the presence of HLA-B53 in individuals is associated with resistance to the disease.

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