Immunological aspects of infections part 8

Immune System

 

Perhaps the best example of an incomplete recognition by the TLR system is a gram negative bacterial infection in the C3H/HeJ mouse. As few as two colony-forming units of Salmonella thypimurium can kill this mouse. Further exploration of this extraordinary virulence revealed that the mouse harbored a point mutation (P712H) in the TLR4, which results in defective signal transduction in response to LPS and a heightened susceptibility to gram-negative infection.

Advertisements

About azaleaazelia

A nice person... :)
This entry was posted in Tak Berkategori. Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s