Basic components of the immune system part 161

 

 

Immune 1

 

Cancer patients and healthy subjects often harbor a repertoire of self-reactive T cells and antibodies. This led to the idea that if one could break  immunological tolerance  to these self-antigens in a controllable manner one would find a “therapeuitic window” in which an autoimmune response might damage cancers more than normal tissues. This approach has worked reasonably well with chemotherapies, which, although not cancer specific, can confer clinical benefit  with acceptable morbidities.

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