Basic components of the immune system part 124

Immune 1

 

IMMUNOSUPPRESSION

Immunosuppresive drugs

Several groups of drugs suppress the immune system. Among the oldest of these drugs are the corticisteroids, which have long been  known to alter immune responses. When corticosteroids are given, the result is  a transient  lymphophenia peaking at four hours and lasting up to twenty-four hours. Helper T cells are predominantly affected, and at higher doses of steroids inhibition of interleukin-2 (IL-2) production by helper T cells becomes increasing important. Another major effect in humans is on resting macrophages (activated macrophages are not sensitive)

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