TYPE II: CELL BOUND
These reactions are initiated by antibody reacting with antigen on the cell membranes. IgM and IgG can be involved in these reactions. Clinical examples include organ-specific autoimmune diseases and immune hemolytic anemia. The role of autosensitized T cells in some diseases such as rheumathoid arthritis and multiple sclerosis have been postulated, but the evidence for their involvement is far from clear. In Grave’s disease (hyperthyroidism), autoantibodies have a primary pathogenic but specific reactive T cells are also present. However, it is not clear whether the T cells exert a primary role in stimulating antibody production or are really secondary to the tissue damage.