Basic components of the immune system part 34

Immune 1



Integrins are heterodimer. These are divided into α and β subunits. Depending on the substructure of the β unit, there are five families, but for convenience β1 and β2 integrins are involved in leucocyte-endothelial interaction. β1 integrins, also known as very late activation proteins, are so named because they appear on lymphocytes several days after antigenic stimulation and are composed of a common β chain (CD29) paired with a different α chain. They mediate lymphocyte and monocyte binding to the endothelium receptors called vascular adhesion molecules. β2 integrins also have a common β chain (CD18), which pairs with different α chains (CD11 a,b,c) to form a number of separate molecules.These two sets of integrins mediate strong binding of leucocytes to the endothelial cell while β3-β5 are concerned with binding to extracellular matrix proteins such as fibronectin and vitronectin.


About azaleaazelia

A nice person... :)
This entry was posted in Tak Berkategori. Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s