HLA antibody testing part 25

HLA antibodies

 

Virtual crossmatch

Antibody testing to identify the correct donor

Despite historical associations of high panel reactive antibody with immunologically poor outcomes, studies with these improved technologies have shown that patients with high panel reactive antibody but not donor-specific HLA antibody have graft and rejection-free survival comparable with unsensitized recipients. Virtual      crossmatch compares recipient antibody specifities with donor antigens permitting  rapid and earlier identification of donor-specific HLA antigen – negative donors in deceased donor acceptable mismatch strategies and living donor paired exchange programs worldwide.

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