HLA antibody testing part 1

HLA antibodies

 

HLA antigens are polymorphic proteins expressed on donor kidney allograft endothelium and are critical targets for recipient immune recognition. HLA antibodies  are risk factors for acute and chronic rejection and allograft loss. Solid-phase immunoassays for HLA antibody  detection represent a major advance in sensitivity and specifity over cell based methods and are widely used in organ allocation  and pretransplant risk assessment. Post-transplant, development of the novo donor-specific HLA antibodies and/or increase in  donor-specific antibodies from pretransplant levels are associated with adverse outcomes. Although single antigen bead assays have allowed sensitive detection of recipient HLA antibodies and their specifities, a number of interpretive considerations must be appreciated to understand test results in  clinical and research contexts.

Advertisements

About azaleaazelia

A nice person... :)
This entry was posted in Tak Berkategori. Bookmark the permalink.

1 Response to HLA antibody testing part 1

  1. Izza says:

    good posting

    Like

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s