HLA antibody testing part 1

HLA antibodies


HLA antigens are polymorphic proteins expressed on donor kidney allograft endothelium and are critical targets for recipient immune recognition. HLA antibodies  are risk factors for acute and chronic rejection and allograft loss. Solid-phase immunoassays for HLA antibody  detection represent a major advance in sensitivity and specifity over cell based methods and are widely used in organ allocation  and pretransplant risk assessment. Post-transplant, development of the novo donor-specific HLA antibodies and/or increase in  donor-specific antibodies from pretransplant levels are associated with adverse outcomes. Although single antigen bead assays have allowed sensitive detection of recipient HLA antibodies and their specifities, a number of interpretive considerations must be appreciated to understand test results in  clinical and research contexts.

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1 Response to HLA antibody testing part 1

  1. Izza says:

    good posting


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