HLA system in solid organ transplantation part 29

histocompatibility testing

 

Available prediction tools like the Immune Epitope Data Base and Analysis Resource could be used to facilitate this enterprise by experienced labs. Furthermore, HLA matching at the T cell epitope or cryoptotope level would be also expected  to be affected by recipient’s polymorphic profile in molecules involved in antigenic peptide generation and perhaps by the T cell receptor repertoire of each recipients (shaped according to their own HLA alleles). It might or not be the right “match” from the HLA match maker but could provide a fair “deal” in the assessment of compatibility between the donor and the recipient (potentially a new tool dubbed as HLA match dealer)

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