HLA system in solid organ transplantation part 19

histocompatibility testing

 

Unfortunately, in transplantation, these properties are counterproductive as the greater the polymorphic variants expressed by a given donor and the greater the alloantigen density on the foreign cells, the strongest the alloresponse and the potential effector rejection mechanisms deployed by the immune system of the recipient. Therefore, it is of pivotal importance to discuss how histocompatibility is defined operationally in the clinical setting for solid organ transplantation.

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