HLA typing in organ transplant part 10

mhc class 1 & ii


First method is serological assay, can be made by antibody-dependent cell-mediated cytotoxicity , or complemen-dependent cytotoxicity. In antibody-dependent cell-mediated cytotoxicity,  the cytotoxic destruction of antibody-coated target cells by host cells is triggered when an antibody bound to the surface of a cell interacts with Fc receptors on natural killer cells or macrophages. Serologic methods was also used in screening for HLA antibodies in the recipient. These antibodies are important because they are reactive with lymphocytes of a prospective donor (cross matching).


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