HLA typing in organ transplant part 2

mhc class 1 & ii

 

The HLA system includes a complex array of genes located on chromosome number 6 and their molecular products that are involved in immune regulation and cellular differentiation. Human leucocyte antigen (HLA) molecules are expressed on all nucleated cells, and they are the major molecules that initiate graft rejection. There are three classical loci at HLA class I(HLA-A, -B and -C) and five loci at class II (HLA-DR, -DQ, –DP, -DM, and -DO).

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