Human Leukocyte Antigen (HLA) part 118

hla protein 1


Several hypotheses have been suggested to explain how variation in HLA class I genes could trigger autoimmunity. HLA class I molecules play a role in presenting endogenous antigens, including those derived from viruses and/or bacteria, which have been proposed to be key enviromental trigger for autoimmune disease. Viral/bacteria antigens may trigger autoimmun disease through molecular mimicry and via acting as superantigens HLA class I molecules  could also be associated with autoimmune disease due to their role in inhibiting natural killer cell activity. Non-viral mechanism have also been proposed including:

  • Protein misfolding causing specific molecules to accumulate in the RER, where they are degraded, potentially causing a pro-inflammatory unfolded protein stress response or misfolded proteins themselves to become autoantigenic
  • Conversion of HLA class I molecules into peptides which could then be presented by HLA class II molecules to the immune system and an immune respones mounted as has been pr0posed in ankylosing spondylitis with B*27
  • Peptide binding and presentation by specific HLA molecules as suggested earlier for HLA class II molecules with mechanisms including selection of antigen-specific CD8 T cells during thymic education, and positive or negative selection of a strong CD8 T suppressor population

About azaleaazelia

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1 Response to Human Leukocyte Antigen (HLA) part 118

  1. inkdropk says:

    Nice to see the little thing that’s been fusing my back up close and personal! Colourful little chappie isn’t he ?


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