Human Leukocyte Antigen (HLA) part 109

hla protein 1


Type I diabetes, a multifactorial disease with a strong genetic component, is caused by the autoimmune destruction of pancreatic β cells. The major type I diabetes susceptibility locus maps to the class II loci HLA-DRB1 and HLA-DQB1 on chromosome 6p21. The highest risk DR/DQ haplotypes for type I diabetes are DR3-DQA1*0501-DQB1*0201(DR3) AND DR4-DQA1*0301-DQB1*0302(DR4), and these alleles account for 30-50% of genetic type I diabetes risk. The association of specific HLA-DQB1 alleles and genotypes with type I diabetes susceptibility/protection depends on the ethnicity and racial background of each population. For example, in Caucasian, type I diabetes is positively associated with DQB1*0201 and DQB1*0302 while in Japanese, it is associated with DQB1*0401 and DQB1*0303


About azaleaazelia

A nice person... :)
This entry was posted in Tak Berkategori. Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s