Human Leukocyte Antigen (HLA) part 108

hla protein 1


HLA and autoimmune disease

Strong association between the HLA region and autoimmune disease has been established for over 50 years. Association of components of the HLA class II encoded HLA-DRB1-DQA1-DQB1 haplotype has been detected with several autoimmune diseases including reumathoid arthritis, type I diabetes and grave’s disease. Molecules encoded by this region play a key role in exogenous antigen presentation to CD4 Th cells, indicating the importance of this pathway in autoimmune disease initiation and progression. Association of the HLA class I region, independent of known HLA class II effects, has now been detected for several autoimmune diseases, including strong association of HLA-B with type I diabetes and HLA-C with multiple sclerosis and grave’s diseases. These results provide  further evidence  of a possible role for bacterial or viral infection and CD8 T cells in autoimmune disease onset.


About azaleaazelia

A nice person... :)
This entry was posted in Tak Berkategori. Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s