Human Leukocyte Antigen (HLA) part 91

hla protein 1

 

There are conflicting data concerning the value of selecting an allelic mismatch over an antigenic mismatch. Petersdorf et al did not find any apparent difference between allele and antigen mismatches with respect to the number of deaths from transplant, suggesting that donors with a single HLA allele antigen mismatch may be used for hematopoietic stem cell transplantation when a fully matched  unrelated donor is not available for patients with severe diseases not permitting time  for lengthy search. There were  no significant differences in survival depending on whether the mismatch was allelic or antigenic mismatch at HLA-C. However, Flomenberg et al found that antigenic mismatch was associated with higher mortality compared to allelic mismatch . They indicated that selection of donors with high-resolution mismatches over those with low-resolution mismatches may lower the rate of post transplant complication.

Advertisements

About azaleaazelia

A nice person... :)
This entry was posted in Tak Berkategori. Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s