Human Leukocyte Antigen (HLA) part 89

hla protein 1

 

Petersdorf summarized the rich history of studies investigating the importance of HLA matching in haematopoietic stem cell tranplant either unrelated donor transplantation  or cord blood transplantation. In unrelated donor hematopoietic stem cells transplantation, there are five major concepts regarding the role of donor HLA mismatching and graft versus host disease :

  • Type and match at high resolution
  • Consider HLA-DP especially HLA-A, C, B, DR, DQ-mathced donors are available
  • When matched donors are not available, limit the total number of HLA mismatches
  • When selecting among HLA-mismatched donors, distinguish allele from antigen mismatches
  • Consider KIR ligands, KIR alleles, and KIR haplotypes

In cord blood transplantation, there is strong evidence that fewer  mismatches are associated with overall improved outcome and that HLA-associated effects are influenced by the cell dose of the cord blood unit. Like unrelated donor hamatopoeitic stem cell transplantation, there is emerging evidence that matching the cord blood unit for HLA-C will lower post-transplant complication.

Advertisements

About azaleaazelia

A nice person... :)
This entry was posted in Tak Berkategori. Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s